Shortly afterwards Serbia and Morea were taken, as were the islands of Limni, Tashos, Midilli, Imros and Eghribos in the Aegean Sea. Mehmed next put an end to the Greek Empire of Trebizond in 1461 and siezed Geonese Colonies in the Crimea. The Crimea was subjected to the Ottoman Empire.
Mehmed declared war against the Akkoyun Empire in 1473 and at the Battle of Otlukbeli he defeated Ouzoun Hassan, the Akkoyun Emperor. With that victory Mehmed the Conqueror annexed the whole of Anatolia as far as the River Euphrates.
In 1480 Gedik Ahmed Pasha began a campaign against Italy. He captured the citadel of Otranto but his own death prevented a complete conquest. Mehmed the Conqueror set out for Egypt but, on his way to do battle at Gebze, he died.
Mehmed was succeeded by his son Bayezid. His brother Djem rebelled against him but was eventually defeated and took refuge in Europe. Bayezid added Herzegovina and Moldavia to his Empire but did not conduct many campaigns while his brother still lived in Europe.
War between the Ottoman and Mameluke Empires began in 1485 and continued for six years, only ending after the Peace of Tunis in 1491. There were many gains for the Ottoman Empire and a rebellion by Shah Ismail began in Anatolia. The rebellion was put down by Hadim Ali Pasha. During Bayezid's last days his sons began to struggle between themselves for the sultanate.
After considerable argument Sultan Bayezid Khan was, either willingly or unwillingly, obliged to hand over power to his son Selim (the Excellent) who had been supported by the Janissaries because of his bravery and courage.